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CVE-2026-31972

samtools mpileup has use-after-free leading to an invalid read

Published: Mar 18, 2026Updated: Mar 19, 2026 Sources: CVE List NVDCWE-416
9.8CVSSCRITICAL

Description

SAMtools is a program for reading, manipulating and writing bioinformatics file formats. The `mpileup` command outputs DNA sequences that have been aligned against a known reference. On each output line it writes the reference position, optionally the reference DNA base at that position (obtained from a separate file) and all of the DNA bases that aligned to that position. As the output is ordered by position, reference data that is no longer needed is discarded once it has been printed out. Under certain conditions the data could be discarded too early, leading to an attempt to read from a pointer to freed memory. This bug may allow information about program state to be leaked. It may also cause a program crash through an attempt to access invalid memory. This bug is fixed in versions 1.21.1 and 1.22. There is no workaround for this issue.

CVSS Vector Breakdown

AV:NAC:LPR:NUI:NS:UC:HI:HA:H
Exploitability
AV:NAttack Vector
Network
AC:LAttack Complexity
Low
PR:NPrivileges Required
None
UI:NUser Interaction
None
Scope
S:UScope
Unchanged
Impact
C:HConfidentiality
High
I:HIntegrity
High
A:HAvailability
High

Weaknesses

Affected Products

Attack Graph

Products CVE Techniques Tactics

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Exploitability

Official Patch Available

MITRE ATT&CK

2 techniques
Initial Access
Privilege Escalation
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References

Timeline

Published
Mar 18, 2026
Last Updated
Mar 19, 2026

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